Author Archives: janice goh
Nonlinear mixed effect modeling – a bed time story
A long time ago before AI generated children’s books were a thing, I made children’s books using biorender for fun. Here’s one that I have not released before. I found it to be a fun way to explain what I … Continue reading
Export control in a digital world – is synthetic data the future for clinical studies?
Part 5 of ScienceJournalJourneys – Hi I am your SG pharmacometrician, an early career researcher here to share the latest trends and interesting facts in pharmacometrics When you bring goods to another country, it is normal for the goods to … Continue reading
Neural ODEs vs ODEs – what’s the difference?
Part 4 of ScienceJournalJourneys – Hi I am your SG pharmacometrician, an early career researcher here to share my expertise and learnings about everything pharmacometrics. For any PK/PD modeler, ODEs are a staple in our models that help us to … Continue reading
ScienceJournalJourney3 – the translation problem in drug development
Drug development often follows a series of experiments of exponentially increasing costs. After identifying a target and a few hits, novel drugs are then tested in large scale against in vitro assays e.g. bacterial kill in a 96 well plate, … Continue reading
ScienceJournalJourney2 – The one surprising use of Fexofenadine (Telfast)
To the average consumer, fexofenadine, or better known by its brand name, Telfast, is a non-sedating anti-allergy medication that can help to stop itches and runny noses. Fexofenadine is an over-the-counter medication that does not require frequent monitoring or dose … Continue reading
Infinity stoned – a pharmacometrician’s take on Thanos in Squid Game 2
Disclaimer: this is purely a tongue in cheek article for educational purposes. In no way do I condone the use of illegal drugs or encourage its use. Also, potential spoilers ahead. Since the season 2 release, Squid Game is once … Continue reading
Has AI taken over my job? A comparison of ChatGPT and DeepSeek for generating NONMEM scripts
Prompt: Develop a 1 compartment oral absorption PK model with linear elimination in NONMEM I did a direct comparison of the script outputs in the table below. For the sake of brevity, only CL was discussed in the $PK block, … Continue reading
ScienceJournalJourney 1: How do drug manufacturers make dosing recommendations?
Hi all, Happy New Year to everyone! I’m starting a new series this year called #ScienceJournalJourney where I review an interesting journal article and give a quick layman summary on it. As your favorite post doc influencer on LinkedIn, I … Continue reading
Taking stock – has LinkedIn been useful for an early career scientist?
Its been slightly over a year since I started posting on LinkedIn. From approximately 300 ish followers, my following has grown to 2590 as of writing. Of note, I am happy to know that my coffee PK app has been … Continue reading
Antibody pharmacokinetics (PK) and nonlinear clearance
Life has been rather busy lately, but I have been using my spare time to learn new things too. Having come from a background working mostly with small molecules, I have decided to take some time to learn about the … Continue reading
Singapore Pharmacometrics 