Category Archives: Coffee Simulator
How to build a PK-PD model?
Hello fellow coffee and cat lovers, as with the first caffeine simulator, I will be going through how to run PK-PD simulations too. Link to coffee simulator 2: https://lnkd.in/dAiS3igB We have previously covered how to run PK simulations which you … Continue reading
Why do pharmacokinetic-pharmacodynamic (PK-PD) modeling?
It takes 2 hands to clap. Previously, in my first coffee simulator, https://janicegoh.shinyapps.io/CoffeeSimulator/ we used a simple threshold to determine caffeine efficacy and toxicity. However, this efficacy alone does not tell us exactly how alert we will be with a … Continue reading
How can I use PK to help my research or clinical practice? (Part 5/5)
Thank you all for staying with me throughout this series! It has been fun sharing about my field with all of you! Over the past few weeks we have played with, and discussed the principles behind the coffee simulator, and … Continue reading
What about variability? (Part 4/5)
Let’s talk about variability. Many of you have correctly highlighted over the past few weeks that coffee absorption can be variable due to a variety of reasons. This not only occurs with coffee but with almost all drugs that we … Continue reading
A guide to running your own simulations (Part 3/5)
A huge aspect of building PK models is simulation, so we can test new scenarios, optimize new dose regimens, and even combine it with a pharmacodynamic (PD) model to build PK-PD models (maybe a future topic? Comment down below). You … Continue reading
What is the coffee simulator based on? (Part 2/5)
The main backbone of the coffee simulator comes from a pharmacokinetic model detailed in this paper by KY Seng et al. https://pubmed.ncbi.nlm.nih.gov/19125908/ Interestingly, there are a lot of papers related to caffeine out there for various purposes, such as defense … Continue reading
Optimizing your coffee dosage – why use modeling and simulation? (Part 1/5)
Hi all, here is a series I originally posted on linkedin as a soft introduction to the wonderful world of pharmacometrics. A lot of these posts revolve around a simple coffee simulator I built for the fun of optimizing your … Continue reading
Singapore Pharmacometrics 