Tag Archives: bioinformatics
Export control in a digital world – is synthetic data the future for clinical studies?
Part 5 of ScienceJournalJourneys – Hi I am your SG pharmacometrician, an early career researcher here to share the latest trends and interesting facts in pharmacometrics When you bring goods to another country, it is normal for the goods to … Continue reading
Neural ODEs vs ODEs – what’s the difference?
Part 4 of ScienceJournalJourneys – Hi I am your SG pharmacometrician, an early career researcher here to share my expertise and learnings about everything pharmacometrics. For any PK/PD modeler, ODEs are a staple in our models that help us to … Continue reading
Antibody pharmacokinetics (PK) and nonlinear clearance
Life has been rather busy lately, but I have been using my spare time to learn new things too. Having come from a background working mostly with small molecules, I have decided to take some time to learn about the … Continue reading
Nobel prize-winning neural nets and pharmacometrics
As a (mostly) computational scientist, I was excited to see both the Nobel prizes in physics and chemistry being awarded for computational work last week. In particular, the Physics price on Artificial neural networks, a fundamental building block in many … Continue reading
How can pharmacometrics benefit clinical practice and vice versa?
Last weekend, I had the privilege of speaking about my work in pharmacogenomics at the Singapore Pharmacy Congress. It was a good time of getting to meet old friends and network with the new generation of pharmacists. Just as how … Continue reading
Direct vs Indirect effect models
When you take a drug, the drug needs time to be absorbed after, it needs to reach the effect site and then cause a biological process to happen before an effect occurs. All these processes take time. Some of them … Continue reading
How to build a PK-PD model?
Hello fellow coffee and cat lovers, as with the first caffeine simulator, I will be going through how to run PK-PD simulations too. Link to coffee simulator 2: https://lnkd.in/dAiS3igB We have previously covered how to run PK simulations which you … Continue reading
What are enteric-coated tablets, and how does enteric coating affect PK?
Most tablets and capsules taken by mouth enter the stomach and dissolve there, before entering the small intestine for absorption. On the other hand, enteric-coated tablets are designed with a special coating to allow the medication to pass through the … Continue reading
Optimizing your vitamin C intake – how much should you really take?
Hello friends, here’s a fun question for you. How many oranges do you need to eat to get the same amount of vitamin C as a 1000mg vitamin C tablet? A quick Google search suggests that a single orange has … Continue reading
Scientific crystal balls – how pharmacometrics is like the weather forecast and why we need it
Hi all, I’m Janice, your SG pharmacometrician. To many of you, pharmacometrics, the study of modeling and simulation of drug levels and their outcomes, probably isn’t a term that comes easily to mind or something that you will regularly come … Continue reading
Singapore Pharmacometrics 