Tag Archives: Pharmacokinetics
How to build a PK-PD model?
Hello fellow coffee and cat lovers, as with the first caffeine simulator, I will be going through how to run PK-PD simulations too. Link to coffee simulator 2: https://lnkd.in/dAiS3igB We have previously covered how to run PK simulations which you … Continue reading
Why do pharmacokinetic-pharmacodynamic (PK-PD) modeling?
It takes 2 hands to clap. Previously, in my first coffee simulator, https://janicegoh.shinyapps.io/CoffeeSimulator/ we used a simple threshold to determine caffeine efficacy and toxicity. However, this efficacy alone does not tell us exactly how alert we will be with a … Continue reading
A sticky situation
Researchers, if your compound It’s not your next big hit. It could be an aggregator instead. These are some general pointers for flagging out false positives when screening for new hits (B. Shiochet PMID: 16793529). As PK scientists, this is also … Continue reading
How do I know two drugs can be safely taken together? – understanding drug-drug interactions
In my previous life as a pharmacist, many patients used to ask if it was safe to take two medications they were prescribed together. Unless otherwise stated e.g. explicit instructions were given to take the medications at least 2 hours … Continue reading
What are enteric-coated tablets, and how does enteric coating affect PK?
Most tablets and capsules taken by mouth enter the stomach and dissolve there, before entering the small intestine for absorption. On the other hand, enteric-coated tablets are designed with a special coating to allow the medication to pass through the … Continue reading
How can our genes affect drug levels?
We all respond to drugs differently. As many of you have pointed out while using the coffee simulator https://janicegoh.shinyapps.io/CoffeeSimulator/ over the past few months, the profile shown there does not always accurately describe your experience with coffee. This is because … Continue reading
Top down vs bottom up pharmacokinetic (PK) modeling – a soft intro
To a person new to PK modeling, understanding the differences between population PK modeling (top down) and physiologically based PK (PBPK) (bottom up) modeling might be confusing. Hopefully, this analogy can help you out. Let’s say you wanted a new … Continue reading
Why does metformin cause a metallic taste in your mouth?
Hi all, life has been pretty busy lately, but I am still trying to post fun things I come across when I can. Hope you enjoy! A common but relatively harmless side effect of metformin is a lingering metallic taste … Continue reading
Can Pipagao be harmful?
As a Singaporean Chinese, I grew up taking a mix of both Traditional Chinese Medicine (TCM) and Western medicine when I fell sick. In particular, one of my favourite medicines a TCM cough medicine, Pipagao. Pipagao is a honey-based, herbal … Continue reading
Optimizing your vitamin C intake – how much should you really take?
Hello friends, here’s a fun question for you. How many oranges do you need to eat to get the same amount of vitamin C as a 1000mg vitamin C tablet? A quick Google search suggests that a single orange has … Continue reading
Singapore Pharmacometrics 