Tag Archives: pharmacology
Export control in a digital world – is synthetic data the future for clinical studies?
Part 5 of ScienceJournalJourneys – Hi I am your SG pharmacometrician, an early career researcher here to share the latest trends and interesting facts in pharmacometrics When you bring goods to another country, it is normal for the goods to … Continue reading
ScienceJournalJourney 1: How do drug manufacturers make dosing recommendations?
Hi all, Happy New Year to everyone! I’m starting a new series this year called #ScienceJournalJourney where I review an interesting journal article and give a quick layman summary on it. As your favorite post doc influencer on LinkedIn, I … Continue reading
Taking stock – has LinkedIn been useful for an early career scientist?
Its been slightly over a year since I started posting on LinkedIn. From approximately 300 ish followers, my following has grown to 2590 as of writing. Of note, I am happy to know that my coffee PK app has been … Continue reading
A quick visual check for saturated clearance
In many animal studies, a wide range of doses are often used. At high doses, it is possible to have way more drug than its clearance pathway can handle, resulting in less drug than expected being eliminated. This is called … Continue reading
Direct vs Indirect effect models
When you take a drug, the drug needs time to be absorbed after, it needs to reach the effect site and then cause a biological process to happen before an effect occurs. All these processes take time. Some of them … Continue reading
How to build a PK-PD model?
Hello fellow coffee and cat lovers, as with the first caffeine simulator, I will be going through how to run PK-PD simulations too. Link to coffee simulator 2: https://lnkd.in/dAiS3igB We have previously covered how to run PK simulations which you … Continue reading
Why do pharmacokinetic-pharmacodynamic (PK-PD) modeling?
It takes 2 hands to clap. Previously, in my first coffee simulator, https://janicegoh.shinyapps.io/CoffeeSimulator/ we used a simple threshold to determine caffeine efficacy and toxicity. However, this efficacy alone does not tell us exactly how alert we will be with a … Continue reading
A sticky situation
Researchers, if your compound It’s not your next big hit. It could be an aggregator instead. These are some general pointers for flagging out false positives when screening for new hits (B. Shiochet PMID: 16793529). As PK scientists, this is also … Continue reading
How do I know two drugs can be safely taken together? – understanding drug-drug interactions
In my previous life as a pharmacist, many patients used to ask if it was safe to take two medications they were prescribed together. Unless otherwise stated e.g. explicit instructions were given to take the medications at least 2 hours … Continue reading
What are enteric-coated tablets, and how does enteric coating affect PK?
Most tablets and capsules taken by mouth enter the stomach and dissolve there, before entering the small intestine for absorption. On the other hand, enteric-coated tablets are designed with a special coating to allow the medication to pass through the … Continue reading
Singapore Pharmacometrics 