Tag Archives: pharmacology
How can our genes affect drug levels?
We all respond to drugs differently. As many of you have pointed out while using the coffee simulator https://janicegoh.shinyapps.io/CoffeeSimulator/ over the past few months, the profile shown there does not always accurately describe your experience with coffee. This is because … Continue reading
Top down vs bottom up pharmacokinetic (PK) modeling – a soft intro
To a person new to PK modeling, understanding the differences between population PK modeling (top down) and physiologically based PK (PBPK) (bottom up) modeling might be confusing. Hopefully, this analogy can help you out. Let’s say you wanted a new … Continue reading
Why does metformin cause a metallic taste in your mouth?
Hi all, life has been pretty busy lately, but I am still trying to post fun things I come across when I can. Hope you enjoy! A common but relatively harmless side effect of metformin is a lingering metallic taste … Continue reading
Can Pipagao be harmful?
As a Singaporean Chinese, I grew up taking a mix of both Traditional Chinese Medicine (TCM) and Western medicine when I fell sick. In particular, one of my favourite medicines a TCM cough medicine, Pipagao. Pipagao is a honey-based, herbal … Continue reading
Optimizing your vitamin C intake – how much should you really take?
Hello friends, here’s a fun question for you. How many oranges do you need to eat to get the same amount of vitamin C as a 1000mg vitamin C tablet? A quick Google search suggests that a single orange has … Continue reading
Going beyond dose – why we need PK parameters
Good morning. In today’s weather report, we are expecting 1000L rain. – said no one ever. If I were to read the weather report before going to work, I intuitively want to know 3 things: the location the rain will … Continue reading
Scientific crystal balls – how pharmacometrics is like the weather forecast and why we need it
Hi all, I’m Janice, your SG pharmacometrician. To many of you, pharmacometrics, the study of modeling and simulation of drug levels and their outcomes, probably isn’t a term that comes easily to mind or something that you will regularly come … Continue reading
Transitioning out from grad school – a year end reflection
2023 was a big year of transition for me. Just this year I graduated from UCSF, published a paper, moved from San Francisco to Singapore to pioneer pharmacometrics research as part of the Research Data Integration Group at BII. One … Continue reading
How can I use PK to help my research or clinical practice? (Part 5/5)
Thank you all for staying with me throughout this series! It has been fun sharing about my field with all of you! Over the past few weeks we have played with, and discussed the principles behind the coffee simulator, and … Continue reading
What about variability? (Part 4/5)
Let’s talk about variability. Many of you have correctly highlighted over the past few weeks that coffee absorption can be variable due to a variety of reasons. This not only occurs with coffee but with almost all drugs that we … Continue reading
Singapore Pharmacometrics 