Tag Archives: pharmacometrics
Why do pharmacokinetic-pharmacodynamic (PK-PD) modeling?
It takes 2 hands to clap. Previously, in my first coffee simulator, https://janicegoh.shinyapps.io/CoffeeSimulator/ we used a simple threshold to determine caffeine efficacy and toxicity. However, this efficacy alone does not tell us exactly how alert we will be with a … Continue reading
Why does metformin cause a metallic taste in your mouth?
Hi all, life has been pretty busy lately, but I am still trying to post fun things I come across when I can. Hope you enjoy! A common but relatively harmless side effect of metformin is a lingering metallic taste … Continue reading
How can I use PK to help my research or clinical practice? (Part 5/5)
Thank you all for staying with me throughout this series! It has been fun sharing about my field with all of you! Over the past few weeks we have played with, and discussed the principles behind the coffee simulator, and … Continue reading
What about variability? (Part 4/5)
Let’s talk about variability. Many of you have correctly highlighted over the past few weeks that coffee absorption can be variable due to a variety of reasons. This not only occurs with coffee but with almost all drugs that we … Continue reading
A guide to running your own simulations (Part 3/5)
A huge aspect of building PK models is simulation, so we can test new scenarios, optimize new dose regimens, and even combine it with a pharmacodynamic (PD) model to build PK-PD models (maybe a future topic? Comment down below). You … Continue reading
Singapore Pharmacometrics 