Tag Archives: singapore pharmacometrics
Has AI taken over my job? A comparison of ChatGPT and DeepSeek for generating NONMEM scripts
Prompt: Develop a 1 compartment oral absorption PK model with linear elimination in NONMEM I did a direct comparison of the script outputs in the table below. For the sake of brevity, only CL was discussed in the $PK block, … Continue reading
ScienceJournalJourney 1: How do drug manufacturers make dosing recommendations?
Hi all, Happy New Year to everyone! I’m starting a new series this year called #ScienceJournalJourney where I review an interesting journal article and give a quick layman summary on it. As your favorite post doc influencer on LinkedIn, I … Continue reading
Taking stock – has LinkedIn been useful for an early career scientist?
Its been slightly over a year since I started posting on LinkedIn. From approximately 300 ish followers, my following has grown to 2590 as of writing. Of note, I am happy to know that my coffee PK app has been … Continue reading
Antibody pharmacokinetics (PK) and nonlinear clearance
Life has been rather busy lately, but I have been using my spare time to learn new things too. Having come from a background working mostly with small molecules, I have decided to take some time to learn about the … Continue reading
Nobel prize-winning neural nets and pharmacometrics
As a (mostly) computational scientist, I was excited to see both the Nobel prizes in physics and chemistry being awarded for computational work last week. In particular, the Physics price on Artificial neural networks, a fundamental building block in many … Continue reading
How can pharmacometrics benefit clinical practice and vice versa?
Last weekend, I had the privilege of speaking about my work in pharmacogenomics at the Singapore Pharmacy Congress. It was a good time of getting to meet old friends and network with the new generation of pharmacists. Just as how … Continue reading
A quick visual check for saturated clearance
In many animal studies, a wide range of doses are often used. At high doses, it is possible to have way more drug than its clearance pathway can handle, resulting in less drug than expected being eliminated. This is called … Continue reading
Direct vs Indirect effect models
When you take a drug, the drug needs time to be absorbed after, it needs to reach the effect site and then cause a biological process to happen before an effect occurs. All these processes take time. Some of them … Continue reading
How to build a PK-PD model?
Hello fellow coffee and cat lovers, as with the first caffeine simulator, I will be going through how to run PK-PD simulations too. Link to coffee simulator 2: https://lnkd.in/dAiS3igB We have previously covered how to run PK simulations which you … Continue reading
Why do pharmacokinetic-pharmacodynamic (PK-PD) modeling?
It takes 2 hands to clap. Previously, in my first coffee simulator, https://janicegoh.shinyapps.io/CoffeeSimulator/ we used a simple threshold to determine caffeine efficacy and toxicity. However, this efficacy alone does not tell us exactly how alert we will be with a … Continue reading
Singapore Pharmacometrics 