Tag Archives: singapore pharmacometrics
A sticky situation
Researchers, if your compound It’s not your next big hit. It could be an aggregator instead. These are some general pointers for flagging out false positives when screening for new hits (B. Shiochet PMID: 16793529). As PK scientists, this is also … Continue reading
How do I know two drugs can be safely taken together? – understanding drug-drug interactions
In my previous life as a pharmacist, many patients used to ask if it was safe to take two medications they were prescribed together. Unless otherwise stated e.g. explicit instructions were given to take the medications at least 2 hours … Continue reading
What are enteric-coated tablets, and how does enteric coating affect PK?
Most tablets and capsules taken by mouth enter the stomach and dissolve there, before entering the small intestine for absorption. On the other hand, enteric-coated tablets are designed with a special coating to allow the medication to pass through the … Continue reading
How can our genes affect drug levels?
We all respond to drugs differently. As many of you have pointed out while using the coffee simulator https://janicegoh.shinyapps.io/CoffeeSimulator/ over the past few months, the profile shown there does not always accurately describe your experience with coffee. This is because … Continue reading
Top down vs bottom up pharmacokinetic (PK) modeling – a soft intro
To a person new to PK modeling, understanding the differences between population PK modeling (top down) and physiologically based PK (PBPK) (bottom up) modeling might be confusing. Hopefully, this analogy can help you out. Let’s say you wanted a new … Continue reading
Can Pipagao be harmful?
As a Singaporean Chinese, I grew up taking a mix of both Traditional Chinese Medicine (TCM) and Western medicine when I fell sick. In particular, one of my favourite medicines a TCM cough medicine, Pipagao. Pipagao is a honey-based, herbal … Continue reading
Optimizing your vitamin C intake – how much should you really take?
Hello friends, here’s a fun question for you. How many oranges do you need to eat to get the same amount of vitamin C as a 1000mg vitamin C tablet? A quick Google search suggests that a single orange has … Continue reading
Scientific crystal balls – how pharmacometrics is like the weather forecast and why we need it
Hi all, I’m Janice, your SG pharmacometrician. To many of you, pharmacometrics, the study of modeling and simulation of drug levels and their outcomes, probably isn’t a term that comes easily to mind or something that you will regularly come … Continue reading
Transitioning out from grad school – a year end reflection
2023 was a big year of transition for me. Just this year I graduated from UCSF, published a paper, moved from San Francisco to Singapore to pioneer pharmacometrics research as part of the Research Data Integration Group at BII. One … Continue reading
A key data science skill all grad students should learn
Hi all, Merry Christmas! Experimenting with posting a slightly different type of content for the Holidays. There has been a lot of hype recently about Artificial Intelligence and data science as the next frontier for humanity’s progress. A quick Google … Continue reading
Singapore Pharmacometrics 